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6. červen 2013 Written by   Published in News

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Aenean iaculis volutpat libero congue hendrerit. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Vivamus tempus tellus eu quam volutpat vehicula. Maecenas eget lorem orci, ut sagittis nulla. Donec non justo tortor, sit amet consequat enim. Mauris volutpat dignissim sagittis. Aliquam suscipit pharetra nibh, vel tincidunt sem lacinia ac. Aliquam vel magna ut dolor sagittis tincidunt. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nullam semper sem sit amet massa lobortis commodo. Nam scelerisque, eros interdum malesuada fermentum, ante ligula molestie quam, vitae eleifend diam lorem eget massa.

 

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    The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
    “This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

    First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

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    The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

    Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

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    Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

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