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Previous studies have also demonstrated that the migration of MSCs to the cancer site is carefully controlled by diffusion cytokines, type interleukin 8 (il-8) and growth factors, including transforming growth factor-beta 1 (tgf-?1), platelet-derived growth factor (PDGF), fibroblast growth factor 2 (FGF-2), vascular endothelial growth factor 81 (VEGF)81 and extracellular matrix molecules, such as matrix metalloproteinase-2 (MMP-2).82 after MSCs successfully migrate into cancerous tissues, data accumulates speaking about cooperation between MSCs and cancer cells, manifested in their antitumor effect, https://TreatmentStemCellItaly.com/, which commonly called basic problems of therapy made from MSC.
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